2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
March 7th, 2025
Version: 1
The University of Chicago
animal behavior and cognition
biorxiv

Genetic vitamin B6 deficiency and alcohol interaction in behavior and metabolism

Wang, B.Open in Google Scholar•Fu, W.Open in Google Scholar•Ueda, A.Open in Google Scholar•Shah, H.Open in Google Scholar•Wu, C.-F.Open in Google Scholar•Chi, W.Open in Google Scholar•Zhuang, X.Open in Google Scholar

Alcohol abuse is a leading cause of preventable deaths, affecting brain function and metabolism, including GABA transmission and vitamin B6 (VB6) levels. However, the interaction between genetic VB6 deficiency and alcohol consumption remains unexplored. Here, we utilized Drosophila models with mutations in pyridox(am)ine-5\'-phosphate oxidase (PNPO), a key enzyme in VB6 metabolism, to examine this interaction at behavioral and biochemical levels. Our findings demonstrate that PNPO deficiency reduces alcohol aversion, increases consumption, and alters locomotor behavior. Biochemically, PNPO deficiency and alcohol exposure converge on amino acid metabolism, elevating inhibitory neurotransmitters GABA and glycine. Moreover, both PNPO deficiency and alcohol exposure lead to lethality with significant interaction, which can be rescued by VB6 supplementation. These results highlight a functional interaction between genetic VB6 deficiency and alcohol, suggesting potential therapeutic strategies for alcohol-related behaviors.

Similar Papers

biorxiv
Fri Mar 07 2025
Decision-making strategies of two related fish species diverge under increased perceptual load
Three main mechanisms have been proposed to explain divergent decisions between species faced with the same options: differences in sensory abilities, attentional capacities, or cognitive evaluations. While these mechanisms have been well-established in controlled settings, there is limited empirical evidence regarding the ways in which different species make decisions under varying perceptual loa...
Tomasek, M.
•
Dunster, B.
•
Goverts, Z.
•
Naceur, D.
...•
Dufour, V.
biorxiv
Fri Mar 07 2025
Decoding Bovine Communication with AI and Multimodal Systems ~ Advancing Sustainable Livestock Management and Precision Agriculture
Achieving sustainability in livestock farming requires advanced, non-invasive monitoring systems that enhance both productivity and animal welfare. Traditional methods for assessing dairy cow ingestive behavior, such as manual observation and sensor-based tracking, are often limited in scalability and accuracy. This study advances precision livestock farming by integrating multimodal artificial in...
Kate, M.
•
Neethirajan, S.
biorxiv
Fri Mar 07 2025
Testing the mediating role of female-male social interactions on the relationship between age and reproductive success.
Differential reproduction is a key driver of evolution that is determined by individual characteristics and mating opportunities, including mate choice. Social interactions between conspecifics are hypothesized to be important in facilitating mate choice and reproductive success but are difficult to measure. Using data from 52 adult barn swallows (Hirundo rustica erythrogaster) whose social intera...
Laubach, Z. M.
•
Keller, K. P.
•
Safran, R. J.
•
Tsunekage, T.
•
Levin, I. I.
biorxiv
Fri Mar 07 2025
Where's my mom? Resilient maternal preference in post-weaning male and female mice within a multi-chamber social behavior task
One of the earliest and most critical social bonds for many mammals is formed with their mother, who provides essential benefits for offspring development and survival. Growing evidence suggests that this social bond is retained even when animals gain independence, such as during the juvenile period immediately post-weaning. Here, we investigated whether juvenile (postnatal day (P)26) mice retain ...
Slamin, M. M.
•
Bishnoi, I. R.
•
Bankowski, I. M.
•
Norris, H. A.
•
Bordt, E. A.
biorxiv
Fri Mar 07 2025
Experimental study of social learning in three wild shell-dwelling Tanganyikan cichlids that vary in sociality
The social intelligence hypothesis posits that animals living in more complex social groups display better cognitive performances. However, this hypothesis has mainly been investigated in primates and studies using similar paradigms across different species are scarce. We tested three species of wild Lamprologine shell-dwelling cichlids from Lake Tanganyika (Neolamprologus multifasciatus, Lamprolo...
Tomasek, M.
•
Dufour, V.
•
Jordan, A. L.
biorxiv
Fri Mar 07 2025
Evidence for social learning in a granivorous passerine bird, and for its independence from personality
Individual learning is a way that animals use to adaptively adjust their behaviour to conditions taking advantage of previous experiences. However, individual learning includes risks and costs that can be overcome by learning from others. Thus, several social and gregarious species, across many taxa, rely on social learning. Despite its relevance, the ability to learn from observation of others be...
Frascotti, A.
•
Silva, R.
•
Mota, P. G.
biorxiv
Fri Mar 07 2025
Bumblebee string-pulling skill spreads between colonies under open diffusion conditions
Socially-transmitted behavioural traits can, if they persist in a group of animals over time, give rise to locally-adapted phenotypes that can enhance survival. This capacity is widespread through the animal kingdom, and forms the foundation of cultural inheritance. While social learning is well-documented among insects, and particularly in social insects such as bumblebees, the extent to which su...
Procenko, O.
•
Bridges, A. D.
•
Kowalewska, A.
•
Juusola, M.
•
Chittka, L.
biorxiv
Fri Mar 07 2025
Rat Hindlimb Amputation Model Shows Analgesia and Sexually Dimorphic Cold Hypersensitivity with Immediate Targeted Muscle Reinnervation
Introduction: Targeted muscle reinnervation (TMR) has been used clinically to reduce pain in amputees but the mechanisms producing analgesia are unknown. Here we employ rat hindlimb amputation as an appropriate model to evaluate algogenic processes affected by TMR, performed at the time of amputation in subjects of both sex. Methods: Adult male and female Sprague-Dawley rats were assigned to amput...
Zepeda, J. L.
•
Mraz, G.
•
Roth, E.
•
Weihrauch, D.
•
Hoben, G.
biorxiv
Fri Mar 07 2025
Unsupervised Approach for Electric Signal Separation in Gnathonemus petersii: Linking Behavior and Electrocommunication
The transfer of information between individuals is fundamental to living systems. Therefore, communication should be studied in various species. Weakly electric fish, Gnathonemus petersii, provides a unique model organism for such investigations due to its advanced electrocommunication capabilities, using electric organ discharges (EODs). Separating EODs from multiple individuals is crucial yet ch...
Chrtkova, I.
•
Koudelka, V.
•
Langova, V.
•
Hubeny, J.
...•
Horacek, J.