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April 1st, 2025
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Laboratorio de Sueno y Memoria, Instituto Tecnologico de Buenos Aires (ITBA)
neuroscience
biorxiv

Caffeine increases false alarms in consolidation of face recognition memory

Leon, C. S.Open in Google Scholar•Lo Celso, A. L.Open in Google Scholar•Guajardo, R.Open in Google Scholar•Forcato, C.Open in Google Scholar

Numerous studies have shown that caffeine facilitates cognition, particularly memory, when consumed before learning and immediately tested. However, most of this evidence relates to its effects during encoding, and the role in memory consolidation remains unclear. A key study demonstrated that caffeine administered after learning can enhance object recognition memory consolidation by improving the discrimination between previously seen targets and similar lures. Here, we investigated the effects of post-encoding caffeine on the consolidation of face recognition memory using a randomized, double-blind design. Participants (N = 104) viewed ten artificially generated faces on Day 1 and then received 200 mg of caffeine or placebo. On Day 2, they completed a recognition task under two conditions: Present condition (original face with five similar distractors) and Absent condition (six similar distractors) adding a -none of the above- option. The results showed that, contrary to our expectation, caffeine consumption did not improve the consolidation of face recognition memory. Instead, it increased False alarm rate in both conditions, reducing the ability to discriminate between previously seen and similar faces. These findings discuss the idea of caffeine as a general cognition enhancer and aligned with studies suggesting it enhances global processing at the expense of detailed discrimination.

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