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April 1st, 2025
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St Jude Children\\\'s Research Hospital
bioinformatics
biorxiv

AlphaSync is an enhanced AlphaFold structure database synchronized with UniProt

Lang, B.Open in Google Scholar•Babu, M. M.Open in Google Scholar

Synchronizing protein structure predictions with sequence databases is crucial for their accuracy. We developed AlphaSync (https://alphasync.stjude.org), a pipeline and database that provides updated AlphaFold structure models for currently 39,961 UniProt proteins, including isoforms. Moreover, AlphaSync enhances 2.6 million structures with residue-level features, including solvent accessibility, dihedral angles, intrinsic disorder predictions, and 4.7 billion atom-level noncovalent contacts. AlphaSync's user-friendly interface enables structural analyses at scale across up-to-date proteomes for 42 species.

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