2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
April 7th, 2025
Version: 1
University College London, U.K.
neuroscience
biorxiv

Distorting anatomy to test MEG models and metrics

Lopez, J. D.Open in Google Scholar•Balbastre, Y.Open in Google Scholar•Ashburner, J.Open in Google Scholar•Bonaiuto, J.Open in Google Scholar•Barnes, G.Open in Google Scholar

Current flow that gives rise to non-invasive Magnetoencephalographic (MEG) data derives predominantly from pyramidal neurons oriented orthogonal to the cortical surface. The estimate of current flow based on extra-cranial magnetic fields is a well-known ill-posed problem; however, this current distribution must depend on anatomy. In other words, a veridical estimate of current flow should discriminate between true and distorted versions of the brain. Here, we make use of advances in diffeomorphic brain shape modelling to construct a set of parametrically deformable cortical surfaces. We use a latent space of 100 components to construct cortical surfaces that are representative of the population. We show how these geometric distortions can be used to quantify the performance of MEG source reconstruction algorithms and metrics of fit.

Similar Papers

biorxiv
Mon Apr 07 2025
Multi-modal brain properties are associated with interindividual differences in fear acquisition and extinction
Interindividual differences in fear acquisition and extinction have been related to variation in specific brain correlates. However, variability in experimental setups complicates the integration of findings. Here, we present a combined fear acquisition (n = 101) and extinction (n = 88) experiment in which both phenomena were related to brain correlates obtained via functional magnetic resonance i...
Fraenz, C.
•
Metzen, D.
•
Packheiser, J.
•
Merz, C. J.
...•
Genc, E.
biorxiv
Mon Apr 07 2025
Neural and Behavioral Changes in Older Adults from Auditory-Cognitive Training
Speech perception in noisy environments is a common challenge among older adults, even for those with clinically normal hearing. Cognitive decline may be one of the contributing factors, and, as such, auditory-cognitive training may enhance speech perception in these conditions. This study aims to determine if auditory-cognitive training can improve speech-in-noise listening in normal-hearing, old...
Fisher, C.
•
Karunathilake, I. M. D.
•
Johns, M. A.
•
Vance, A.
...•
Simon, J. Z.
biorxiv
Mon Apr 07 2025
Spatiotemporal differences of GABAergic polarization and shunting during dendritic integration
In the adult brain, GABA exerts either depolarizing or hyperpolarizing effects on neuronal membranes, depending on neuron type, subcellular location, and neuronal activity. Depolarizing GABA typically inhibits neurons through shunting, which is characterized by increased membrane conductance upon GABAA receptor activation; however, it can also excite neurons by recruiting voltage-dependent conduct...
Dembitskaya, Y.
•
Kirsanov, A.
•
Wu, Y.-W.
•
Brazhe, A.
•
Semyanov, A.
biorxiv
Mon Apr 07 2025
Steady-state neuron-predominant LINE-1 encoded ORF1p protein and LINE-1 RNA increase with aging in the mouse and human brain
Recent studies have established a reciprocal causal link between aging and the activation of transposable elements, characterized in particular by a de-repression of LINE-1 retrotransposons. These LINE-1 elements represent 21% of the human genome, but only a minority of these sequences retain the coding potential essential for their mobility. LINE-1 encoded proteins can induce cell toxicity implic...
Bonnifet, T.
•
Sinnassamy, S.
•
Massiani-Beaudoin, O.
•
Mailly, P.
...•
Fuchs, J.
biorxiv
Mon Apr 07 2025
Distinct cerebrospinal fluid DNA methylation signatures linked to Alzheimer's disease
Alzheimer's disease (AD) accounts for more than 60% of the dementia cases and currently there is no curative treatment for it. With the emergence of potentially disease modifying treatments, early diagnosis is key to identify patient groups that would benefit from such treatments, aiming to prevent severe cognitive decline. We previously identified a set of DNA methylation signatures that allow fo...
Rados, M.
•
Klotz, S.
•
Regelsberger, G.
•
Stögmann, E.
...•
Fetahu, I. S.
biorxiv
Mon Apr 07 2025
Resting-state alpha and mu rhythms change shape across development but lack diagnostic sensitivity for ADHD and autism
In the human brain, the alpha rhythm in occipital cortex and the mu rhythm in sensorimotor cortex are among the most prominent rhythms, with both rhythms functionally implicated in gating modality-specific information. Separation of these rhythms is non-trivial due to the spatial mixing of these oscillations in sensor space. Using a computationally efficient processing pipeline requiring no manual...
Bender, A.
•
Voytek, B.
•
Schaworonkow, N.
biorxiv
Mon Apr 07 2025
Longitudinal multimodal neuroimaging after traumatic brain injury
Traumatic brain injury is a major cause of long term cognitive impairment, yet the mechanisms underlying recovery remain poorly understood. Neuroimaging methods such as diffusion MRI, functional MRI, and positron emission tomography (PET) provide insight into micro and macro scale changes post TBI, but the relationships between regional cellular and functional alterations remain unclear. In this s...
Radanovic, A.
•
Jamison, K. W.
•
Kang, Y.
•
Shah, S.
•
Kuceyeski, A.
biorxiv
Mon Apr 07 2025
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
The locus coeruleus (LC), the major source of norepinephrine (NE) in the brain, is among the earliest site of pathology in both Alzheimers disease (AD) and Parkinsons disease (PD), and it undergoes catastrophic degeneration later in both disorders. Dysregulation of the LC is thought to contribute to prodromal symptoms of AD and PD such as anxiety and sleep disturbances, while frank LC loss promote...
Iannitelli, A. F.
•
Hassanein, L.
•
Tish, M. M.
•
Mulvey, B.
...•
Weinshenker, D.
biorxiv
Mon Apr 07 2025
Fast-spiking neurons in monkey orbitofrontal cortex underlie economic value computation
Inhibitory interneurons are fundamental constituents of cortical circuits that process information to shape economic behaviors. However, the role of inhibitory interneurons in this process remains elusive at the core cortical reward-region, orbitofrontal cortex (OFC). Here, we show that presumed parvalbumin-containing GABAergic interneurons (fast-spiking neurons, FSNs) cooperate with presumed regu...
Murakawa, T.
•
Kawai, T.
•
Imaizumi, Y.
•
Yamada, H.