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April 11th, 2025
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biochemistry
biorxiv

In vitro Activity of Citrus IntegroPectin against Breast Cancer and Colon Cancer

D'Anna, C.Open in Google Scholar•Di Sano, C.Open in Google Scholar•Li Petri, G.Open in Google Scholar•Angellotti, G.Open in Google Scholar•Ciriminna, R.Open in Google Scholar•Pagliaro, M.Open in Google Scholar

In vitro investigations of citrus IntegroPectin bioconjugates obtained through acoustic cavitation in water of different citrus fruit (lemon, red orange, and sweet orange) processing waste revealed the conjugate\'s ability to inhibit the migratory features of Caco-2 colon cancer and MCF-7 breast cancer cells. All tested pectins substantially reduced cell migration of both tumor cell lines already at 0.5 and 1.0 mg/mL concentration. Dissolved in aqueous phase, furthermore, red orange and lemon IntegroPec-tin phytocomplexes at 5 and 10 mg/mL load reduced cell viability for both cell lines. Adding to promising results against lung can-cer, these outcomes support further investigation of In-tegroPectin citrus pectins for the treatment of cancer.

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