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May 8th, 2025
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Max Planck Institute for Human Cognitive and Brain Sciences
neuroscience
biorxiv

Somatosensory high frequency oscillations across the human central nervous system

Bailey, E.Open in Google Scholar•Nierula, B.Open in Google Scholar•Stephani, T.Open in Google Scholar•Waterstraat, G.Open in Google Scholar•Curio, G.Open in Google Scholar•Nikulin, V.Open in Google Scholar•Eippert, F.Open in Google Scholar

Information transmission in the central nervous system (CNS) relies on the propagation of action potentials (neuronal spikes), traditionally thought to be inaccessible with electroencephalography (EEG). Converging evidence from human and animal recordings however demonstrates that high frequency oscillations (HFOs) in EEG recordings represent neuronal population spiking, complementing standard low-frequency EEG recordings in cortex. Here, we developed an approach to simultaneously record HFOs to somatosensory stimulation across the entire human CNS noninvasively: from spinal over subcortical to cortical stages. Our approach provides a detailed temporal and spectral characterization of HFOs at each CNS level, delineating how they evolve across the somatosensory processing hierarchy. Critically, we show that low and high frequency electrophysiological responses represent at least partly independent processing channels across the CNS. We thus demonstrate the feasibility of studying the full spectrum of neuronal information processing across the CNS, offering a multi-level window into human neurophysiology in health and disease.

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