2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
June 3rd, 2025
Version: 1
Yonsei University
bioengineering
biorxiv

Hand Drawing Image based Causal Representation Learning for Robust Parkinson's Disease Feature Extraction and Detection

Kim, D.Open in Google Scholar

Being an irreversible disorder regarding the human motor-system, Parkinson\'s Disease(PD) has been a threat to many neurological patients, especially due to its severity in pain and muscle control restriction. As PD has no significant cure or treatments to this day, early diagnosis, or detections of PD within potential patients is a crucial task to maximize the effect of mediations which are implemented to achieve temporal prohibition of motor failure progression. In recent research, alongside conventional diagnosis methods based on neurological examinations or MRI based brain imaging, use of deep learning based artificial intelligence models, such as CNN, are repeatedly reported to have significant progress in detecting PD in early stages with high performance. Based on current success, this research attempted to further enhance AI-driven PD diagnosis by developing a deep learning based causal representation learning framework that extracts only highly robust PD features from simple hand drawings. Specifically, convolutional VAE based reconstruction and information theory based weakly supervised learning were linked with causal representation learning methods to distinguish significant PD features from geometrical features within hand drawing images. Not only aiding conventional tests for PD diagnosis, but also giving reliable representations of PD features such as tremor and rigidity, developed framework was found to achieve high performance in both retrieving latent factors of PD in images and predicting PD diagnosis results.

Similar Papers

biorxiv
Thu Jun 05 2025
Mixotrophy for carbon-conserving waste upcycling
Modern chemical production, on which human quality of life depends, is unsustainable. Alternative, sustainable manufacturing routes must therefore be developed. Electrochemical and biological processes offer promise for upgrading waste streams, including recalcitrant carbon dioxide and plastic-derived wastes. However, these processes are challenged by the inherent heterogeneity and high energy inp...
Weldon, M.
•
Euler, C.
biorxiv
Thu Jun 05 2025
Pathwise approximations to solving the filtering problem for the stochastic chemostat
This paper concerns the inverse problem of characterising the state of a bioreactor from observations. In laboratory settings, the bioreactor is represented by a device called a chemostat. We consider a differential description of the evolution of the state of the chemostat under environmental fluctuations. First, we model the state evolution as a stochastic process driven by Brownian motion. Unde...
Fontenele Magalhaes, J. A.
•
Emzir, M. F.
•
Corona, F.
biorxiv
Thu Jun 05 2025
A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity via engineered Gro3P-Glycerol shunt
Dihydroxyacetone phosphate (DHAP), glycerol-3-phosphate (Gro3P) and reduced/oxidized nicotinamide adenine dinucleotide (NADH/NAD+) are key metabolites of the Gro3P shuttle system that forms a redox circuit, allowing transfer of reducing equivalents between cytosol and mitochondria. Targeted activation of Gro3P biosynthesis was recently identified as a promising strategy to alleviate reductive stre...
Pan, X.
•
Munan, S.
•
Zuckerman, A. L.
•
Pon, A.
...•
Cracan, V.
biorxiv
Thu Jun 05 2025
Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cell Adhesion to Bioactive Hydrogels
Endothelialization promotes thromboresistance in blood-contacting devices, but biomaterial designs often overlook sex differences in endothelialization processes. In this study, we elucidated sex differences in endothelial cell-material interactions through investigation of the integrin-ligand interplay with biomaterial substrates and the corollary effects on cell adhesion and spreading. First, in...
Nkansah, A.
•
Budhwani, A.
•
Grammer, N.
•
Ang, N.
...•
Cosgriff-Hernandez, E.
biorxiv
Thu Jun 05 2025
Inhalable Perfluorocarbon Nanocapsules for RNA-based Immunotherapeutic Treatment of Lung Metastases
While chemotherapy and pulmonary metastasectomy are leading clinical treatments for lung metastases, their effectiveness is limited by high recurrence rates and systemic side effects. Preclinical treatments have shown the promise of inhalation-based RNA therapy as a viable approach that can circumvent first pass metabolism and reduce systemic exposure. Here, we develop an inhalable perfluorocarbon...
Siddhanta, K.
•
Monirvaghef, A.
•
Sundar, A.
•
Pinkerton, B. R.
...•
Oupicky, D.
biorxiv
Thu Jun 05 2025
De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors
G protein-coupled receptors (GPCRs) play key roles in physiology and are central targets for drug discovery and development, yet the design of protein agonists and antagonists has been challenging as GPCRs are integral membrane proteins and conformationally dynamic. Here we describe computational de novo design methods and a high throughput "receptor diversion" microscopy based screen for generati...
Muratspahic, E.
•
Feldman, D.
•
Kim, D. E.
•
Qu, X.
...•
Tate,
biorxiv
Thu Jun 05 2025
Precise MRI-Histology Coregistration of Paraffin-Embedded Tissue with Blockface Imaging
Magnetic resonance imaging (MRI) provides 3D spatial information on tissue, yet it lacks at the molecular level. In contrast, histology provides cellular and molecular information, but it lacks the 3D spatial context and direct in vivo translation. Coregistering the two is key for the 3D-embedding of histological details, validating pathological MRI findings, and finding quantitative imaging bioma...
Wang, Y.
•
Ho, W.
•
Huszar, I. N.
•
DiGiacomo, P.
...•
Zeineh, M.
biorxiv
Thu Jun 05 2025
Characterization of Sex-Based Differences in Integrin-Mediated Endothelial Cel Adhesion to Bioactive Hydrogels
Endothelialization promotes thromboresistance in blood-contacting devices, but biomaterial designs often overlook sex differences in endothelialization processes. In this study, we elucidated sex differences in endothelial cell-material interactions through investigation of the integrin-ligand interplay with biomaterial substrates and the corollary effects on cell adhesion and spreading. First, in...
Nkansah, A.
•
Budhwani, A.
•
Grammer, N.
•
Ang, N.
...•
Cosgriff-Hernandez, E.
biorxiv
Thu Jun 05 2025
Engineered Fluorescent Carbon Dots for Selective Cellular Bioeffects: A Comparative Study of Cancer and epithelial Cells
Cancer remains one of the most critical global health challenges, with early detection being essential for effective treatment and improved survival rates. However, conventional diagnostic tools often fail to detect cancer at early stages due to limitations such as low sensitivity, high cost, and dependence on large tumour presence. Commercial dyes used for imaging are frequently hindered by poor ...
Kumar, A.
•
Yadav, P.
•
Bhatia, D. D.
biorxiv
Wed Jun 04 2025
Unifying the Electron Microscopy Multiverse through a Large-scale Foundation Model
Accurate analysis of electron microscopy (EM) images is essential for exploring nanoscale biological structures, yet data heterogeneity and fragmented workflows hinder scalable insights. Pretrained on large, diverse datasets, image foundation models provide a robust framework for learning transferable representations across tasks. Here, we introduce EM-DINO, the first image foundational model pret...
He, L.
•
Shi, R.
•
Wang, W.
•
Cai, Y.
•
Ma, L.