Visual search in natural environments involves numerous objects, each composed of countless features. Despite this complexity, our brain efficiently locates targets. Here, we propose that the brain combines multiple reference cues to form an internal reference frame that facilitates real-world visual search. Objects in natural scenes often appear in orientations perceived as upright, enabling quicker recognition. However, how object orientation influences real-world visual search remains unknown. Moreover, the contributions of different reference cues--egocentric, visual context, and gravitational--are not well understood. To answer these questions, we designed a visual search task in virtual reality. Our results revealed an orientation effect independent of set size, suggesting reference frame transformation rather than object rotation. By rotating virtual scenes and participants in a flight simulator, we found that allocentric cues drastically altered search performance. These findings provide novel insights into the efficiency of real-world visual search and its connection to multimodal cognition.