2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
July 17th, 2025
Version: 1
Dept. of Neurobiology, Center for Neural Circuits and Behavior, Dept. of Neurosciences, University of California San Diego, La Jolla CA USA; Halicio?lu Data Sci
neuroscience
biorxiv

Complementary cortical and thalamic contributions to cell-type-specific striatal activity dynamics during movement

Gjoni, E.Open in Google Scholar•Sristi, R. D.Open in Google Scholar•Liu, H.Open in Google Scholar•Dror, S.Open in Google Scholar•Lin, X.Open in Google Scholar•O'Neil, K.Open in Google Scholar•Arroyo, O. M.Open in Google Scholar•Hong, S. W.Open in Google Scholar•Kim, H.Open in Google Scholar•Liu, J.Open in Google Scholaret al.

Coordinated motor behavior emerges from information flow across brain regions. How long-range inputs drive cell-type-specific activity within motor circuits remains unclear. The dorsolateral striatum (DLS) contains direct- and indirect-pathway medium spiny neurons (dMSNs and iMSNs) with distinct roles in movement control. In mice performing skilled locomotion, we recorded from dMSNs, iMSNs, and their cortical and thalamic inputs identified by monosynaptic rabies tracing. An RNN classifier and clustering analysis revealed functionally heterogeneous subpopulations in each population, with dMSNs preferentially activated at movement onset and offset, and iMSNs during execution. Cortical and thalamic inputs were preferentially activated during onset/offset and execution, respectively, though dMSN- and iMSN-projecting neurons in each region showed similar patterns. Locomotion phase-specific rhythmic activity was found in a subset of thalamic dMSN-projecting neurons and dMSNs. Cortex or thalamus inactivation reduced MSN activity. These findings suggest that corticostriatal and thalamostriatal inputs convey complementary motor signals via shared and cell-type-specific pathways.

Similar Papers

biorxiv
Fri Jul 18 2025
Transcriptomic analysis reveals new reparative mechanisms of SCF and GCSF - reduced neuropathology in aged APPPS1 mice
Alzheimers Disease, AD, is a neurodegenerative disease characterized by amyloid plaque deposition, tau hyperphosphorylation, neuroinflammation, and cognitive decline. Our previous studies showed that combined treatment with stem cell factor, SCF, and granulocyte colony stimulating factor, GCSF, reduces AD pathology in APPPS1 mice. This study aimed to explore the molecular mechanism underlying SCF ...
Addo, A.
•
Li, B.
•
Murikinati, S.
•
Gardner, R.
•
Zhao, L.-R.
biorxiv
Fri Jul 18 2025
The relationship between sleep and cognitive performance on tests of pattern separation
Study objectives: Sleep disturbances are considered both a risk factor and symptom of dementia. The present research aimed to identify cognitive tests in which performance is associated with objective sleep quality or quantity, focusing on cognitive tests designed to evaluate the earliest cognitive changes in dementia. Methods: We recruited younger and older adults and remotely monitored their sle...
Roenningen, A. E.
•
Gill, D.
•
Kent, B. A.
biorxiv
Thu Jul 17 2025
Developmental Stage-Dependent Transcriptomic Responses to Neonatal Intraventricular Hemorrhage
Neonatal intraventricular hemorrhage (IVH) is a major complication of preterm birth, yet how developmental stage influences the brains response to injury remains unclear. We performed single-nucleus RNA sequencing on rat brains 24 hours after IVH at postnatal day 2 (PND2) or day 5 (PND5) to define transcriptional responses across cell types. We identified 42 distinct cell populations and found tha...
Wallace-Anthony, E.
•
Zamorano, M.
•
Vekaria, H. J.
•
Oldham, B. B.
...•
Miller, B. A.
biorxiv
Thu Jul 17 2025
Investigating the Effects of Synbiotic Intervention on Working Memory, Attention, and Inhibitory Control in Healthy Young Women
The gut-brain axis plays a key role in the bidirectional communication between the gastrointestinal system and the brain, with gut microbiota significantly influencing cognitive function. While synbiotic and probiotic interventions have shown potential cognitive benefits, results across studies remain mixed. This randomized, controlled, repeated-measures study investigated the effects of a 15-day ...
Salimi, Y.
•
Namdarzadeh, B.
•
Dehghani-Arani, F.
•
Vahabie, A.-H.
•
Rezayat, E.
biorxiv
Thu Jul 17 2025
Variants in glycine decarboxylase activate mechanisms of mitochondrial energy metabolism in the brain.
Brain energy metabolism is produced from glucose by mitochondrial oxidative phosphorylation. Variants in the mitochondrial enzyme glycine decarboxylase (GLDC) cause a rare neurological disease, non-ketotic hyperglycinemia (NKH), with expected hallmarks of brain glycine elevation and responsiveness to folate deficiency that are equivalent to the severity of Gldc mutations. We remarkably find that b...
Haldar, K.
•
Lopez-Ramirez, A.
•
Worth, A.
•
Wang, Z.
...•
Padmanabhan, P.
biorxiv
Thu Jul 17 2025
Bmal1 expression is minimal or absent in human and mouse cerebral microglia
Microglia orchestrate immunological responses in the brain and play an important role in maintaining homeostatic brain functions. Several studies have reported clock gene expression in microglia and the circadian rhythm they drive has been linked to the modulation of immune responses and neuronal functions. In the current study, complementary approaches, including immunofluorescence, multiplexed f...
Rahimian, R.
•
Simard, S.
•
Chawla, A.
•
Zhu, L.
...•
Mechawar, N.
biorxiv
Thu Jul 17 2025
Motor learning drives region-specific transcriptomic remodeling in the motor cortex and dorsal striatum
Motor learning depends on coordinated activity across the motor cortex (M1) and dorsal striatum (dSTR), yet the molecular mechanisms driving learning-related synaptic and circuit remodeling remain unclear. Here, we combine activity-dependent genetic labeling (TRAP) with single-cell RNA sequencing to generate an unbiased, cell type-resolved transcriptional atlas of behaviorally engaged populations ...
Sun, Y.
•
Roth, R. H.
•
Hwang, F.-J.
•
Wang, S.
•
Ding, J. B.
biorxiv
Thu Jul 17 2025
Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1
Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity1-5 that functions as a paracrine factor crucial for glioma growth. Here, we elucidate the mechanistic pathway whereby shed NLGN3 interacts with glioma and their normal glial counterpart. NLGN3 in...
Gillespie, S. M.
•
Kim, Y. S.
•
Geraghty, A. C.
•
Yalcin, B.
...•
Monje, M.
biorxiv
Thu Jul 17 2025
Diet context gates AgRP neuron involvement in Semaglutide-induced weight loss
Semaglutide, a GLP-1R agonist, is widely used for obesity and type 2 diabetes, but its neural mechanisms remain unclear. AgRP neurons regulate energy balance, yet their role in the effects of Semaglutide is unknown. We show that sustained treatment of female mice with Semaglutide leads to activation rather than inhibition of AgRP neurons. Ablation or hypofunction of AgRP neurons through cell-speci...
d'Avila, M.
•
Collado-Perez, R.
•
Liu, Z.
•
Horvath, T.
biorxiv
Thu Jul 17 2025
Bounds on the computational complexity of neurons due to dendritic morphology
The simple linear threshold units used in many artificial neural networks have a limited computational capacity. Famously, a single unit cannot handle non-linearly separable problems like XOR. In contrast, real neurons exhibit complex morphologies as well as active dendritic integration, suggesting that their computational capacities outperform those of simple linear units. Considering specific fa...
Agrawal, A.
•
Buice, M. A.