2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
January 22nd, 2025
Version: 1
Cornell University
evolutionary biology
biorxiv

Bayesian phylodynamic inference of population dynamics with dormancy

Cappello, L.Open in Google Scholar•Lo, W. T. J.Open in Google Scholar•Zhang, J. Z.Open in Google Scholar•Xu, P.Open in Google Scholar•Barrow, D.Open in Google Scholar•Chopra, I.Open in Google Scholar•Clark, A. G.Open in Google Scholar•Wells, M. T.Open in Google Scholar•Kim, J.Open in Google Scholar

Many organisms employ reversible dormancy, or seedbank, in response to environmental fluctuations. This life-history strategy alters fundamental eco-evolutionary forces, leading to distinct patterns of genetic diversity. Two models of dormancy have been proposed based on the average duration of dormancy relative to coalescent timescales: weak seedbank, induced by scheduled seasonality (e.g., plants, invertebrates), and strong seedbank, where individuals stochastically switch between active and dormant states (e.g., bacteria, fungi). The weak seedbank coalescent is statistically equivalent to Kingman\'s coalescent with a scaled mutation rate, allowing the use of existing inference methods. In contrast, the strong seedbank coalescent differs fundamentally, as only active lineages can coalesce, while dormant lineages cannot. Additionally, dormant individuals typically mutate at a slower rate than active ones. Despite the significant role of dormancy in the eco-evolutionary dynamics of many organisms, no methods currently exist for inferring population dynamics and associated parameters involving dormancy. We present a Bayesian framework for jointly inferring a latent genealogy, seedbank parameters, and evolutionary parameters from molecular sequence data under the strong seedbank coalescent. We derive the exact probability density of genealogies sampled under the strong seedbank coalescent, characterize the corresponding likelihood function, and present efficient computational algorithms for its evaluation based on our theoretical framework. We develop a tailored Markov chain Monte Carlo sampler and implement our inference framework as a package SeedbankTree within BEAST2. Our work provides both a theoretical foundation and practical inference framework for studying the population genetic and genealogical consequences of dormancy.

Similar Papers

biorxiv
Tue Jul 01 2025
The transcriptome of the mosquito host Anopheles gambiae upon infection by different selected lines of the microsporidian parasite Vavraia culicis
Understanding host-parasite interactions is of the utmost importance for disease prediction, prevention and management. Hence, this study assessed the transcriptional response of the primary malaria vector Anopheles gambiae, to infection with several lines of the candidate vector-control parasite, the microsporidian Vavraia culicis. These parasite lines were selected for early or late transmission...
Silva, L. M.
biorxiv
Tue Jul 01 2025
G protein-coupled receptor diversity and evolution in the closest living relatives of Metazoa
G protein-coupled receptors (GPCRs) play a pivotal role in the perception of environmental cues across eukaryotic diversity. Although GPCRs have been relatively well characterized in metazoans, GPCR signaling is poorly understood in their sister group, the choanoflagellates, and in other close relatives of metazoans (CRMs). Here, we examine GPCR diversity and evolution in choanoflagellates by cura...
Garcia De Las Bayonas, A.
•
King, N.
biorxiv
Tue Jul 01 2025
Experimental validation of genome-environment associations in Arabidopsis
Identifying the genetic basis of local adaptation is a key goal in evolutionary biology. Allele frequency clines along environmental gradients, known as genotype-environment associations (GEA), are often used to detect potential loci causing local adaptation but are rarely followed by experimental validation. Here, we tested loci identified in three moisture-related GEA studies on Arabidopsis. We ...
Luo, Y.
•
Lorts, C.
•
Lawrence-Paul, E.
•
Lasky, J.
biorxiv
Tue Jul 01 2025
SelNeTime: a python package inferring effective population size and selection intensity from genomic time series data
Genomic samples collected from a single population over several generations provide direct access to the genetic diversity changes occurring within a specific time period. This provides information about both demographic and adaptive processes acting on the population during that period. A common approach to analyze such data is to model observed allele counts infinite samples using a Hidden Marko...
Uhl, M.
•
Bunel, P.
•
de Navascues, M.
•
boitard, s.
•
Servin, B.
biorxiv
Mon Jun 30 2025
Genetic variation in life-history traits is not correlated with estrogen-receptor positive breast cancer risk
Estrogen-receptor positive breast cancer (ER+ BC) is one of the most prevalent cancers, but the evolutionary processes shaping genetic variation in ER+ BC risk are poorly understood. Here, we explore evidence for antagonistic pleiotropy between ER+ BC risk and human life-history traits, testing whether increased genetic ER+ BC risk is indicative of life-history trade-offs, and is associated with f...
Young, E. A.
•
Erten, E. Y.
•
Postma, E.
•
Lummaa, V.
...•
Dugdale, H. L.
biorxiv
Mon Jun 30 2025
Temperature and pH universally govern protein diversity in hydrothermal spring communities, but they do so differently
It has been suggested that temperature and pH are strong explanatory causes of protein evolutionary constraint. However, a general understanding of how changes in temperature and pH may universally impact protein evolution is lacking. Moreover, while pH is locally regulated in the different microbial compartments (e.g. periplasm, cytoplasm), temperature is not. A priori, these variables should act...
Rivas-Santisteban, J.
•
Alcorta, J.
•
Diez, B.
•
Tamames, J.
•
Pedros-Alio, C.
biorxiv
Mon Jun 30 2025
Lifestyles shape genome size and gene content in fungal pathogens
Fungi display a wide range of lifestyles and hosts. We still know little about the impact of lifestyles, including pathogenicity, on their genome architecture. Here, we combined and annotated 552 fungal genomes from the class Sordariomycetes and examined the association between 13 genomic and two lifestyle traits: pathogenicity and insect association. We found that pathogens on average tend to hav...
Fijarczyk, A.
•
Hessenauer, P.
•
Hamelin, R. C.
•
Landry, C. R.
biorxiv
Mon Jun 30 2025
Reduced regulatory complexity associated with the evolutionary transition to sociality from cockroaches to termites despite evolutionary parallels with Hymenoptera
The degree of phenotypic diversity within social species has previously been associated with more complex genetic regulation both in cis and trans contexts. Transcription factors (TFs) being key to genetic regulation, have been studied in the origins of eusociality in Hymenoptera (bees, ants and wasps) but less so in Blattodea (cockroaches and termites). Here we show that the social transition in ...
Jones, A.
•
Dohmen, E.
•
Berger, J.
•
Legendre, F.
...•
Bornberg-Bauer, E.
biorxiv
Mon Jun 30 2025
Improved Genotype Inference Reveals Cis- and Trans-Driven Variation in the Loss-of-Heterozygosity Rates in Yeast
Loss-of-heterozygosity (LOH) events are an important source of genetic variation in diploids and are implicated in cancer. LOH-event rates vary across the genome and across genetic backgrounds, but our understanding of this variation is in its infancy. State-of-the-art measurements of LOH rates are obtained from mutation accumulation (MA) experiments in heterozygous hybrids and hinge on the accura...
Overton, M. S.
•
Kryazhimskiy, S.
biorxiv
Mon Jun 30 2025
Chromatin accessibility differences between the hybrids of nasuta-albomicans complex of Drosophila
Understanding how chromosomal rearrangements (CRs) interact with epigenetic changes to drive speciation is a fundamental question in evolutionary biology. CRs are key contributors to chromosome evolution and can play a pivotal role in reproductive isolation. The Drosophila nasuta-albomicans species complex presents an ideal model to explore this, as D. albomicans possesses neo-sex chromosomes form...
Padma, R.
•
Patil, A. B.
•
Vijay, N.