2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
April 3rd, 2025
Version: 1
KU Leuven
bioengineering
biorxiv

Advancing EEG Biosensing: Novel Scalable Production of Platinum-Silicon Microneedles

Amir, M.Open in Google Scholar•Ding, R.Open in Google Scholar•Rusli, N. I.Open in Google Scholar•Vercooren, N.Open in Google Scholar•Ceyssens, F.Open in Google Scholar•Kuznetsova, N.Open in Google Scholar•Bertrand, A.Open in Google Scholar•Kraft, M.Open in Google Scholar•Taurino, I.Open in Google Scholar

This study presents the development and analysis of a silicon microneedle electrode array fabricated using a streamlined, two-step approach for enhanced bio-signal recording applications. Numerical simulations with COMSOL Multiphysics were employed to optimize the microneedle array design, focusing on mechanical stability and minimizing skin-electrode impedance. Structural analysis identified needle lengths between 500 m and 700 m as optimal for mechanical robustness, with critical load factors indicating a high resistance to buckling under applied forces. Optimal needle spacing was determined to prevent inter-needle interference and ensure effective skin penetration. Proof-of-concept electroencephalography testing confirmed that the microneedles achieved reliable bio-signal recording, comparable to traditional wet electrodes, while offering advantages such as reduced preparation time and improved user comfort. This work establishes a simple and cleanroom-compatible, scalable method for fabricating platinum-coated silicon microneedle arrays, advancing the development of wearable, user-friendly biopotential monitoring devices.

Similar Papers

biorxiv
Fri Apr 04 2025
Embolization-on-a-chip: Novel Vascularized Liver Tumor Model for Evaluation of Cellular and Cytokine Response to Embolic Agents
Background: Embolization is a well-established treatment modality for liver cancer. However, traditional embolization agents are limited by inefficient delivery and aggregation in blood vessels. Novel shear-thinning hydrogels have been developed to address the need for safer and more effective local delivery of embolic agents and therapeutics. Objective: To evaluate the efficacy of novel embolic a...
Nguyen, H. T.
•
Tirpakova, Z.
•
Peirsman, A.
•
Maity, S.
...•
Jucaud, V.
biorxiv
Thu Apr 03 2025
Intracochlear pressure measurements quantify overall noise exposure to the inner ear during mastoidectomy
Introduction The acoustic trauma patients are exposed to during otologic surgery is unclear, as previous studies have not captured the effects of vibrational noise on the inner ear. To fill this knowledge gap, we examined inner ear noise directly via intracochlear pressure changes during a mastoidectomy and cochleostomy. Methods Inner ear stimulation was measured using fiber optic pressure sensors...
Bacalao, E.
•
Lee, N.
•
Ruiz, J.
•
Herrmann, B.
•
Greene, N. T.
biorxiv
Thu Apr 03 2025
PiP-plex: A Particle-in-Particle System for Multiplexed Quantification of Secreted Proteins by Single Cells
Cell signaling is modulated by the secretion of various proteins, which can be used to infer a cells phenotype. However, these proteins cannot be readily detected in multiplex by commonly used methods at the single-cell level. Here, we present a particles-in-particle (PiPs) concept comprising fluorescence intensity barcoded microparticles (BMPs) co-entrapped with a single cell inside an alginate h...
Lussier, F.
•
Moon, B.-U.
•
Janta-Polczynski, M.
•
Morocz, Y.
...•
Juncker, D.
biorxiv
Thu Apr 03 2025
3D Printed Molds for Organ-on-a-Chip and Fluidics: PDMS-Based Rapid and Accessible Prototyping
The ability to rapidly fabricate custom polydimethylsiloxane (PDMS) devices is central to advancing organ-on-a-chip (OoC) technologies and other biological microplatforms. However, traditional photolithography and the surface roughness of directly 3D printed molds limit their accessibility and scalability of PDMS-based systems. Photolithographic workflows are limited by their dependence on special...
Abbed, R. J.
•
Cruz, E. I. Q.
•
Leggett, S. E.
biorxiv
Thu Apr 03 2025
Paired Analyses of Nuclear Protein Targets and Genomic DNA by Single-Cell Western Blot and Single-Cell PCR
Single-cell multimodal assays measure multiple layers of molecular information. Existing single-cell tools have limited capability to analyze nuclear proteins and genomic DNA from the same originating single cell. To address this gap, we designed and developed a microfluidic single-cell assay (SplitBlot), that pairs measurements of genomic DNA (PCR-based) and nucleo-cytoplasmic proteins (nuclear h...
Gomez Martinez, A. E.
•
Lam, T.
•
Herr, A.
biorxiv
Thu Apr 03 2025
A Novel Aptamer-Based Approach for Lipoprotein Removal to Achieve Ultra-Pure Blood EV Isolation
Blood extracellular vesicles (EVs) are nanoscale lipid-bilayer particles that carry proteins, nucleic acids, and metabolites, rendering them powerful tools for non-invasive liquid biopsy and targeted drug delivery. However, clinical translation of blood-derived EVs is severely limited by the co-isolation of lipoproteins, whose size (30 - 100nm) and density overlap with EVs, resulting in contaminat...
Jeon, S.
•
Kim, Y.
•
SHIN, S.
biorxiv
Wed Apr 02 2025
Functional Neural Connectivity of the Mouse Brain using Photoacoustic Ultrasound Imaging
Brain connectomes are insightful models that describe the connectivity of different regions throughout the brain. These connectomes are traditionally generated through correlation of oxygen data from Functional magnetic resonance imaging (fMRI) scans. Photoacoustic ultrasound (PAU) can also detect oxygenation levels while being more accessible and cost effective than fMRI. We propose the use of PA...
Clark, I. H.
•
Heinmiller, A.
•
Zhu, W.
•
Zhu, X.-H.
...•
Chen, W.
biorxiv
Wed Apr 02 2025
Strengthening Antisense Oligonucleotide-Mediated Anti-Tumor Immunity via Metal-Organic Framework Nanoparticles
Overexpression of checkpoint proteins, such as programmed death ligand one (PD-L1), prevents immune recognition and enables cancer growth. Current monoclonal antibodies that block PD-L1 tend to be fragile, unable to penetrate tumors, and target cancer at later stages, thus leading to inconsistent patient outcomes. Antisense oligonucleotides (ASOs) provide an alternative to decrease PD-L1 expressio...
Nowak, J. A.
•
Cho, E.
•
Davis, M. A.
•
Zheng, S.
...•
Teplensky, M. H.
biorxiv
Wed Apr 02 2025
Toward De Novo Protein Design from Natural Language
De novo protein design represents a fundamental pursuit in protein engineering, yet current deep learning approaches remain constrained by their narrow design scope. Here we present Pinal, a large-scale frontier framework comprising 16 billion parameters and trained on 1.7 billion protein-text pairs, that bridges natural language understanding with protein design space, translating human design in...
Dai, F.
•
You, S.
•
Wang, C.
•
Fan, Y.
...•
Yuan, F.