2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
June 6th, 2025
Version: 1
Concordia University
biophysics
biorxiv

The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function

Sanami, S.Open in Google Scholar•Tremblay, S. A.Open in Google Scholar•Rezaei, A.Open in Google Scholar•Potvin-Jutras, Z.Open in Google Scholar•Sabra, D.Open in Google Scholar•Intzandt, B.Open in Google Scholar•Gagnon, C.Open in Google Scholar•Mainville-Berthiaume, A.Open in Google Scholar•Wright, L.Open in Google Scholar•Gayda, M.Open in Google Scholaret al.

Background: Coronary artery disease (CAD) is the leading cause of mortality worldwide and is associated with an increased incidence of cognitive decline, however the pathological mechanisms linking CAD to brain and cognitive health remain unclear. Prior research has identified regional deficits in cerebral blood flow (CBF) and cerebrovascular reactivity (CVR), a measure of vascular reserve, in patients with CAD. However, the impact of these cerebrovascular deficits on cognition has not been explored, nor has the effect of CAD on cerebral metabolic health. This study aims to fill these gaps by investigating how CAD influences cerebral vascular and metabolic health, and how these alterations relate to cognitive function across multiple domains. Methods: Quantitative magnetic resonance imaging (MRI) was employed to measure a comprehensive profile of cerebral vascular and metabolic health, including CBF, CVR, cerebral metabolic rate of oxygen (CMRO2), and oxygen extraction fraction (OEF). Cognition was assessed using a validated neuropsychological battery from which composite scores were extracted, reflecting executive functions, working memory, processing speed, and verbal episodic memory. Results: A total of 35 patients with CAD and 37 healthy controls were included in the final analysis. Patients with CAD demonstrated widespread impairments in both cerebral vascular and metabolic health, characterized by lower CBF , CVR, and CMRO2, and increased OEF, indicative of insufficient oxygen delivery. Notably, lower CVR was associated with poorer executive function, suggesting a specific role of vascular reserve for preserving executive functions. Furthermore, higher OEF was associated with poorer working memory, showing the importance of preserved oxygen consumption for maintaining cognitive function. Conclusion: This study reveals that CAD is associated with impaired cerebral vascular and metabolic health, providing a pathological basis for cognitive decline. Specifically, reduced CVR and elevated OEF emerged as sensitive biomarkers linking impaired brain health and cognition. These markers hold promise for guiding future interventions aimed at preserving cognitive health in patients with CAD.

Similar Papers

biorxiv
Fri Jun 06 2025
Pressure-distance curves of identical and dissimilar lipid membrane surfaces in water
Investigations of the hydration repulsion between hydrophilic soft interfaces in water, in particular between lipid membranes, rely on accurate experimental measurements of the associated pressure-distance curves. Conventional experimental approaches face challenges especially when it comes to the pressure-distance curves between dissimilar surfaces, a scenario with particular value for the study ...
Bange, L.
•
Soltwedel, O.
•
Seibel, D.-E.
•
von Klitzing, R.
•
Schneck, E.
biorxiv
Fri Jun 06 2025
A High-Throughput, Flow Cytometry Approach to Measure Phase Behavior and Exchange in Biomolecular Condensates
Biomolecular condensates are essential for cellular organization, yet their formation dynamics and molecular content exchange properties remain poorly understood. In this study, we developed a high-throughput flow cytometry approach to quantify condensate formation, molecular colocalization, and dynamic exchange. Using self-interacting NPM1 condensates as a model system, we benchmarked the use of ...
He, Y.
•
Ongwae, G. M.
•
Mondal, A.
•
Mittal, J.
•
Pires, M.
biorxiv
Fri Jun 06 2025
In silico design and validation of high-affinity RNA aptamers for SARS-CoV-2 comparable to neutralizing antibodies
Nucleic acid aptamers hold promise for clinical applications, yet understanding their molecular binding mechanisms to target proteins and efficiently optimizing their binding affinities remain challenging. Here, we present CAAMO (Computer-Aided Aptamer Modeling and Optimization), which integrates in silico aptamer design with experimental validation to accelerate the development of aptamer-based R...
Yang, Y.
•
Qiao, L.
•
Jiang, Y.
•
Wang, Z.
...•
Zhou, R.
biorxiv
Fri Jun 06 2025
Amendable decisions in living systems
A distinct feature of living systems is their capacity to take decisions based on uncertain environmental signals. Examples span from the microscopic scale of cells differentiating based on the concentration of a morphogene, to the macroscopic scale of decisions by animals or human beings. The current paradigm in decision theory is based on the assumption that decisions, once taken, cannot be revo...
Neri, I.
•
Pigolotti, S.
biorxiv
Fri Jun 06 2025
Protein phase change batteries drive innate immune signaling and cell fate
How minute pathogenic signals trigger decisive immune responses is a fundamental question in biology. Classical signaling often relies on ATP-driven enzymatic cascades, but innate immunity frequently employs death fold domain (DFD) self-assembly. The energetic basis of this assembly is unknown. Here, we show that specific DFDs function as energy reservoirs through metastable supersaturation. Chara...
Rodriguez Gama, A.
•
Miller, T.
•
Venkatesan, S.
•
Lange, J. J.
...•
Halfmann, R.
biorxiv
Fri Jun 06 2025
Folding and knotting of biotic and pre-biotic amino acid sequences through reverse evolution
We develped a simple reverse evolution method to explore the protein folding transition and knotting process in globular proteins throughout evolution using as a proxy for evolutionary time the lenght of the amino acid alphabet. Three small proteins were considered. An unknotted one featuring a beta-sandwhich fold (FN3), a protein embedding a shallow trefoil knot (MJ0366), and a deeply knotted tre...
Especial, J. N.
•
Faisca, P. F.
biorxiv
Fri Jun 06 2025
All-optical Diamond Heater-Thermometer enables versatile and reliable thermal modulation of ion channels at the single-cell level
A living cell is a nonequilibrium thermodynamic system where, nevertheless, a notion of local equilibria exists. This notion applies to all micro- and nanoscale aqueous volumes, each containing a large number of molecules. This allows one to define sets of local conditions, including thermodynamic ones; for instance, a defined temperature requires thermodynamic equilibrium by definition. Once such...
Rougier, J.-S.
•
Glushkov, E.
•
Guichard, S.
•
Kucera, J.
...•
Abriel, H.
biorxiv
Fri Jun 06 2025
Tissue-like compression stiffening in biopolymer networks induced by aggregated and irregularly shaped inclusions
Biological tissues experience mechanical compression under various physiological and pathological conditions and often exhibit compression stiffening, in which their stiffness increases during compression, a phenomenon that plays a crucial role in regulating cell behavior and maintaining mechanical homeostasis. However, most isolated biopolymer networks, such as fibrin and collagen hydrogels that ...
Shi, X.
•
Shivers, J. L.
•
MacKintosh, F. C.
•
Janmey, P. A.
biorxiv
Fri Jun 06 2025
A myosin hypertrophic cardiomyopathy mutation disrupts the super-relaxed state and boosts contractility by enhanced actin attachment
Hypertrophic cardiomyopathy (HCM) is a leading cause of cardiac failure among individuals under 35. Many genetic mutations that cause HCM enhance ventricular systolic function, suggesting that these HCM mutations are hypercontractile. Among the most common causes of HCM are mutations in the gene MYH7, which encodes for beta-cardiac myosin, the principal human ventricular myosin. Previous work has ...
Cail, R. C.
•
Barua, B.
•
Baez-Cruz, F. A.
•
Winkelmann, D. A.
...•
Ostap, E. M.