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September 2nd, 2025
Version: 1
Georgia Institute of Technology
neuroscience
bioRxiv

Electrical stimulation elicits space- and parameter-dependent spiking responses in human cortical organoids

Nigrisoli, D.Open in Google Scholar•Seseri, N.Open in Google Scholar•Faraci, F.Open in Google Scholar•D'Angelo, A.Open in Google Scholar•Freddi, R.Open in Google Scholar•Chandran, S.Open in Google Scholar•Barbieri, R.Open in Google Scholar•Corti, S.Open in Google Scholar•Ottoboni, L.Open in Google Scholar•Russo, S.Open in Google Scholar

Electrical stimulation (ES) is used to treat neuropsychiatric disorders and investigate brain dynamics, yet its effects on human cortical microcircuits remain poorly understood. Cortical organoids provide a unique platform to investigate these mechanisms in isolation from subcortical and long-range cortical inputs. Here we illustrate how cortical organoids respond to ES, identifying the response profiles of isolated cortical circuits while detailing a roadmap of how ES parameters affect the organoid spiking activity. We employed a high-density multielectrode array to record neuronal activity from cortical organoids (n=417 units in N=7 organoids) during ES, systematically varying stimulation frequency, intensity, pulse width, and charge density. By analyzing single unit spiking activity, we found that ES elicits excitatory, inhibitory, and mixed responses in 39%, 12%, and 17% of the units, respectively. On average, this response lasted 100 ms and became stable within 26 trials. The magnitude of both excitatory and inhibitory responses was maximal near the stimulation site and decayed with distance. The response magnitude was inversely correlated with pulse intensity and duration, but not with stimulation frequency and charge density. These findings demonstrate that local cortical circuits are sufficient to initiate the early excitatory phase of the canonical ES response, whose magnitude depends on ES parameters, and can sustain the excitatory phase for over 100 ms. The reduced late inhibitory phase, together with the absence of late excitatory components observed 200 ms after ES in intact adult brains in-vivo, suggests that these phases may depend on neuronal maturation or inter-area connections. Our work thus establishes cortical organoids as a framework for studying the local contributions to ES-induced activity in a developmental model of the human cortex.

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