2025 Hyper Recent •CC0 1.0 Universal

This work is dedicated to the public domain. No rights reserved.

Access Preprint From Server
September 3rd, 2025
Version: 1
Karolinska Institution
neuroscience
bioRxiv

Memory-Related Default-Executive Coupling Across the Lifespan and Associations with Changes in Cognitive Control

Blakstad, E. G.Open in Google Scholar•Sneve, M.Open in Google Scholar•Vidal-Pineiro, D.Open in Google Scholar•Walhovd, K. B.Open in Google Scholar•Fjell, A. M.Open in Google Scholar•Grydeland, H.Open in Google Scholar

Episodic memory and cognitive control declines in aging. The default-executive coupling hypothesis of aging (DECHA) suggests that a neural correlate of cognitive decline in aging is increased functional connectivity (FC) between lateral prefrontal areas and the default mode network. Here, in a lifespan sample (n=552, 6-81years), we tested FC between the left dorsolateral prefrontal cortex (dLPFC) and the default mode network (DMN) during the encoding and retrieval phases of an episodic memory fMRI task. We created two age groups based on evidence for episodic memory decline after 30 years: a youth group encompassing childhood, adolescence, and young adulthood (6-29 years) and an aging group (30-81 years). To test if the dLPFC-DMN FC was associated with changes in cognitive control, we used longitudinal change (up to 10 years) in a Stroop inhibition/switching task linked to the prefrontal cortex. Results showed (i) lower dLPFC and DMN connectivity with age in the youth group and higher connectivity in the aging group, and (ii) this FC was associated with an age-related increase in the inhibition task completion time, particularly in the aging group. However, dLPFC showed similar relationships with other networks, particularly salient attentional and control subnetworks, and despite decline in cognitive control associated with memory performance, memory-related FC between dLPFC and DMN did not. Although this link with memory performance remains unclear, the results using longitudinal cognitive data align with the DECHA mechanisms and extends the current proposal by indicating inverse relationships in development and the relevance of additional attentional and control network coupling.

Similar Papers

bioRxiv
Thu Sep 04 2025
Astrocytic lysosome deficits reduce alpha-synuclein degradation and induce spread of pathology
Parkinson\'s Disease (PD) is a neurodegenerative disorder caused by the loss of dopaminergic neurons in the substantia nigra due to Lewy body aggregates, primarily composed of misfolded alpha-synuclein (Syn). While PD progression is thought to be driven by a prion-like spread of Syn aggregates between neurons, the role of astrocytes remains unclear. Observations of Syn pathology in PD patient astr...
Roth, L.
•
Morozova, O.
•
Stoehr, J.
•
Schapansky, J.
bioRxiv
Thu Sep 04 2025
Role of Thalamus in Human Conscious Perception Revealed by Low-Intensity Focused Ultrasound Neuromodulation
The neural basis of consciousness remains incompletely understood. While cortical mechanisms of conscious perception have been extensively investigated in humans, the role of subcortical structures, including the thalamus, remains less explored. Here, we elucidate the causal contributions of different thalamic regions to conscious perception using transcranial low-intensity focused ultrasound (LIF...
Jang, H.
•
Fotiadis, P.
•
Mashour, G. A.
•
Hudetz, A. G.
•
Huang, Z.
bioRxiv
Thu Sep 04 2025
Developing a model of temporomandibular disorder in the common marmoset using nerve growth factor
Developing an animal model that more closely represents the human multidimensional pain experience is an important step towards addressing the current chronic pain crisis. The common marmoset has potential as this model species given its biological, neurological and phylogenetic similarity to humans. Here, we developed a model of myofascial temporomandibular disorder (TMD) in the marmoset by injec...
Holzscherer, E. J.
•
Kersten, R.
•
Bertrand, M.
•
Khokhar, J. Y.
...•
Seminowicz, D. A.
bioRxiv
Thu Sep 04 2025
A Developmental Atlas of the Drosophila Nerve Cord Uncovers a Global Temporal Code for Neuronal Identity
The assembly of functional neural circuits relies on the generation of diverse neural types with precise molecular identity and connectivity. Unlocking general principles of neuronal specification and wiring across the nervous system requires a systematic and high-resolution characterisation of its diversity, recently enabled by advances in single-cell transcriptomics and connectomics. However, li...
Cachero, S.
•
Mitletton, M.
•
Beckett, I. R.
•
Marin, E. C.
...•
Dona, E.
bioRxiv
Thu Sep 04 2025
Children with Autism Show Impaired Oculomotor Entrainment to Predictable Stimuli
Individuals with Autism Spectrum Disorder (ASD) show altered synchronization with external events, which may underlie the rigidity and reduced adaptability that characterize the condition. We previously demonstrated that electroencephalography (EEG) recorded from children with ASD reveals impaired neuronal entrainment to predictable visual sequences. Whether similar effects are reflected in other ...
Beker, S.
•
Kadosh, O.
•
Foxe, J. J.
•
Molholm, S.
•
Bonneh, Y. S.
bioRxiv
Thu Sep 04 2025
Alzheimer's subtypesA supervised, unsupervised, multimodal, multilayered embedded recursive (SUMMER) AI study
Since Alzheimer's disease (AD) is a heterogeneous disease, different subtypes may have distinct biological, genetic, and clinical characteristics, requiring tailored interventions. While several proposed subtypes of AD exist, there is still no clear consensus on a definitive classification. By leveraging complementary AI approaches, including supervised and unsupervised learning, within a recursiv...
Kinreich, S.
•
Bingly, A.
•
Pandey, G.
bioRxiv
Wed Sep 03 2025
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formation of myelin sheaths thus involves efficient trafficking and sorting of future myelin constituents via vesicles that fuse with prospective myelin membranes by exocytotic mechanisms. However, the functi...
Siems, S. B.
•
Jung, R. B.
•
Jahn, O.
•
Meschkat, M.
...•
Werner, H. B.
bioRxiv
Wed Sep 03 2025
Single-molecule imaging reveals activity-dependent regulation of Camk2a mRNAs at dendritic spines
Postsynaptic calcium/calmodulin-dependent protein kinase type II (CaMKII) integrates fleeting Ca2+ transients into long-term synaptic potentiation (LTP). A persistent presence of CaMKII at dendritic spines during the maintenance of LTP facilitates the prolongation of synaptic transmission. Yet, it remains unclear how the perpetuation of CaMKII, despite protein turnover, is achieved at dendritic sp...
Hwang, D.-W.
•
Krishnamurthy, K.
•
Nagare, A.
•
Singer, R. H.
•
Das, S.
bioRxiv
Wed Sep 03 2025
Enriched experience increases reciprocal synaptic connectivity and coding sparsity in higher-order cortex
The integration of new information during sleep reshapes cortical representations that support categorical knowledge. Auto-associative attractor network theories predict that reciprocal excitatory connections help form stable categorical attractors, but direct evidence is missing. We tested this using ten weeks of enriched experience (ENR) in mice as a model for knowledge accumulation and recorded...
Saxena, R.
•
Shobe, J. L.
•
Andujo, A. M.
•
Ning, W.
...•
McNaughton, B. L.