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September 3rd, 2025
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West China Hospital of Sichuan University
developmental biology
bioRxiv

A Novel 3D Visualization Method in Mice Identifies the Periportal Lamellar Complex (PLC) as a Key Regulator of Hepatic Ductal and Neuronal Branching Morphogenesis

Xu, T.Open in Google Scholar•Cao, F.Open in Google Scholar•Zhou, R.Open in Google Scholar•Chen, Q.Open in Google Scholar•Zhong, J.Open in Google Scholar•Wang, Y.Open in Google Scholar•Xiao, C.Open in Google Scholar•Yin, B.Open in Google Scholar•Chen, C.Open in Google Scholar•Zhao, C.Open in Google Scholar

The liver\'s microenvironment consists of interconnected vascular, biliary, and neural networks that regulate homeostasis and disease progression. However, the lack of high-resolution 3D visualization hinders our understanding of their interactions in health and pathology. In this study, we developed a high-resolution multiplex 3D imaging method integrating multicolor metallic compound nanoparticle (MCNP) perfusion and optimized CUBIC tissue clearing, enabling simultaneous 3D visualization of the portal vein, hepatic artery, bile ducts, and central vein spatial networks in mouse liver. Using this approach, we identified a novel perivascular structure, the Periportal Lamellar Complex (PLC), regularly distributed along the portal vein axis between its endothelium and the periportal lobule sinusoid. The PLC contains a unique population of CD34+Sca-1+ dual-positive endothelial cells with a distinct gene expression profile, potentially linked to bile acid transport, biliary epithelial cell proliferation, and neural development. Under normal physiological conditions, the PLC colocalizes with terminal bile duct branches and sympathetic nerve fibers. During liver fibrosis progression, the PLC dynamically extends into liver lobules alongside advancing fibrosis, acting as a scaffold guiding the migration of bile ducts and nerve fibers into the hepatic parenchyma. Differential gene expression and GO enrichment analyses further revealed neurodevelopmental and axon guidance pathway enrichment in the CD34+Sca-1+ endothelial population of PLC during fibrosis.\n\nCollectively, these findings establish the PLC as a critical structural and functional hub integrating hepatic vascular, biliary, and neural systems to regulate liver function. This study advances our understanding of liver biology and offers potential therapeutic targets for liver diseases.

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